Yaba Monkey Tumor Virus

As the global outbreak of the monkeypox virus has emerged, viruses similar to the monkeypox virus have moved into the limelight. To prevent the spread of zoonotic diseases caused by these viruses, such as the Yaba monkey tumor virus (YMTV), Creative Biolabs provides reliable virus products and innovative platforms to understand the characteristics of viruses and their infectious virus life cycles as well as technologies to develop antiviral agents. Creative Biolabs' products and services will efficiently streamline the process from mechanistic to clinical translational research of the YMTV.

Background of Yaba Monkey Tumor Virus

The Yaba monkey tumor virus is a type of DNA poxvirus belonging to the genus Yatapoxvirus. It was first found in a colony of rhesus monkeys in Yaba, Lagos, Nigeria in 1956. While many poxviruses are host specific, the YMTV can not only infect and cause cutaneous nodules in primates, including rhesus monkeys, baboons, and cynomolgus monkeys, but also infect humans and cause mild and localized skin disease. Transmission of the YMTV from primates to humans and non-human primates is via trauma and/or insect bites. The YMTV infection primarily occurs in fibroblastic and macrophage cells, leading to cell transformation and the formation of neoplastic-like lesions. The cutaneous lesions caused by YMTV infection can be spontaneously resolved in monkeys after 2-3 months of infection and show only mild symptoms in humans. The excision of cutaneous tumors and subsequent therapy with antibiotics to stop infection of the open wounds are currently the most well-known treatments for the YMTV infection. In order to prevent the large-scale spread of the YMTV, the mechanisms associated with virus replication need to be elucidated. The development of novel drugs is also needed to treat cutaneous and systemic diseases caused by the infection.

Fig.1 Yaba monkey tumor virus infection in a vervet monkey. (Brettschneider, 2013)

Yaba Monkey Tumor Virus Services at Creative Biolabs

Creative Biolabs is dedicated to offering precocious technologies, in vitro and in vivo platforms, and expeditious antiviral drug development solutions for the YMTV. Our comprehensive products associated with the YMTV comprise polymerase chain reaction (PCR) related products for YMTV detection, recombinant proteins and peptides, antibodies, and cell lines for viral studies, and other viral products. In addition, Creative Biolabs also offer anti-YMTV drug discovery solutions targeting viral nucleic acids, polymerases, proteases, fusion proteins, interferons, and other cellular targets to interdict the infectious virus lifecycle. If you have the intention to learn more about Yaba monkey tumor virus products and drug development solutions, please do not hesitate to contact us. Our professional team will design the best solution for you as soon as possible to accelerate your research process.

Reference

1. Brettschneider, H.; et al. Molecular detection of Yaba monkey tumour virus from a vervet monkey. Journal of the South African Veterinary Association. 2013, 84(1): 1-5.