Anti-Monkeypox Drug Discovery Solutions
Online inquiry

We DO NOT PROVIDE ANY PRODUCTS OR SERVICES DIRECTLY TO PATIENTS. All of our products are for Research Use Only (RUO), NOT intended for diagnostic, therapeutic, or clinical use.

* Name
* Phone
* Email
* Products or Services Interested
Project Description
Inquiry
Now

Monkeypox A17L Antibody Development Service

A17L Background

A17L, a viral envelope protein, is a core structural component critical to the assembly and release of the Monkeypox virus. As a key player in the morphogenesis of the viral envelope, A17L is indispensable for viral replication and infectivity. The A17L protein plays a critical role in the lifecycle of the Monkeypox virus (MPXV), making it an essential target for research aimed at understanding viral mechanisms and developing tools for diagnostic and analytical applications. Leveraging over years of expertise in antibody development, Creative Biolabs is a trusted provider of comprehensive A17L-specific antibody development services.

A17L Specific Antibody Development Services

Creative Biolabs offers a range of A17L-specific antibody development services designed to address various research needs. Our comprehensive workflow integrates state-of-the-art platforms, proprietary technologies, and experienced scientists to ensure optimal outcomes.

Custom Antibody Development

Our services include the generation of monoclonal and polyclonal antibodies against A17L using diverse platforms such as hybridoma, phage display, and single B-cell screening.

  • Antigen Design and Preparation: We provide precise antigen preparation services, including recombinant protein production and peptide synthesis tailored to A17L.
  • Immunization and Screening: Using optimized immunization protocols, we generate high-quality immune responses, followed by rigorous screening processes to isolate A17L-specific candidates.

Antibody Humanization and Engineering

For applications requiring enhanced antibody properties, Creative Biolabs excels in engineering solutions:

  • Humanization: We modify rodent-derived antibodies to reduce immunogenicity while retaining affinity.
  • Affinity Maturation: Advanced techniques are applied to improve binding strength to A17L.
  • Isotype Switching and Fc Optimization: Customized isotype designs cater to specific research applications.

Large-Scale Antibody Production and Purification

Once validated, our platform supports scalable production of A17L antibodies, ensuring consistent quality for further analysis or application.

MoA of A17L in Monkeypox

Role in Viral Morphogenesis

A17L is critical for the formation and stability of the viral envelope, contributing to the structural integrity of the virion. During viral morphogenesis, A17L interacts with other viral proteins to mediate the budding and assembly processes required for the generation of infectious viral particles.

Host Immune Evasion

A17L has been implicated in evading host immune responses by masking viral components or influencing the trafficking of immune-modulatory proteins. These functions highlight the importance of A17L as a research target for understanding MPXV pathogenesis.

A17L related Products

A17L Antibodies

Cat# Product Name Target Antibody Isotype Species Reactivity Applications
MPYF-1122-KX1630 Anti-Squirrel Parapoxvirus A17L Monoclonal Antibody (MP-K2430) (Mouse IgG) A17L Mouse IgG Squirrel Parapoxvirus WB (Other applications need to be tested)
MPYF-1022-KX1642 Anti-Variola (Smallpox) Virus A17L Monoclonal Antibody (MP-K1576) (Mouse IgG) A17L Mouse IgG Variola (Smallpox) Virus WB (Other applications need to be tested)
MPYF-1022-KX1382 Anti-Vaccinia Virus (Smallpox Vaccine) A17L Monoclonal Antibody (MP-K1316) (Mouse IgG) A17L Mouse IgG Vaccinia Virus (Smallpox Vaccine) WB (Other applications need to be tested)
MPYF-0822-YF116 Anti-Monkeypox Virus A17L Monoclonal Antibody (MP-W81) (Mouse IgG) A17L Mouse IgG Monkeypox Virus WB (Other applications need to be tested)

A17L Recombinant Proteins & Peptides

Cat# Product Name Species Expression System Target Protein Protein Length
MPYF-0922-KX777 Magic™ Variola (Smallpox) Virus (India-1967, Ind5) A17L Recombinant Protein Variola (Smallpox) Virus Based on specific requirements A17L Full length
MPYF-0722-KX230 Magic™ Monkeypox virus (Zaire-96-I-16) A17L Recombinant Protein Monkeypox virus Based on specific requirements A17L Full Length
MPYF-1022-KX766 Magic™ Squirrel Parapoxvirus (Red squirrel UK) A17L Recombinant Protein Squirrel Parapoxvirus Based on specific requirements A17L Full Length
MPYF-0922-KX517 Magic™ Vaccinia Virus (Smallpox Vaccine) (Western Reserve) A17L Recombinant Protein Vaccinia Virus (Smallpox Vaccine) Based on specific requirements A17L Full length

A17L PCR Primers & Probes

Cat# Product Name Species Target
MPYF-0722-KX1432 Monkeypox virus, A17L-F Monkeypox virus A17L
MPYF-0722-KX1623 Monkeypox virus, A17L-R Monkeypox virus A17L

A17L Plasmids

Cat# Product Name Species Target
MPYF-0722-KX1241 Magic™ Monkeypox virus A17L Expression Plasmid Monkeypox virus A17L

Our Platforms and Technologies

Creative Biolabs employs cutting-edge platforms and proprietary technologies to ensure the success of A17L antibody development:

Phage Display Technology

Rapid screening and identification of A17L-specific antibody candidates.

Single B-Cell Technology

Precise isolation and characterization of naturally occurring antibodies.

Hybridoma Technology

Reliable production of monoclonal antibodies.

High-Throughput Screening

Accelerated candidate validation through advanced automation.

Applications of A17L Antibodies

The applications of A17L-specific antibodies including:

  • Viral Pathogenesis Research: Investigate the role of A17L in Monkeypox lifecycle and immune evasion.
  • Diagnostic Development: Utilize A17L antibodies in assay platforms for detecting Monkeypox virus.
  • Basic Virology Studies: Explore protein-protein interactions and host-pathogen dynamics.

Why Choose Our A17L Antibody Development Services

Creative Biolabs provides professional A17L antibody development services. Choosing us ensures:

  • Comprehensive Expertise: Our extensive experience in antibody discovery and engineering ensures robust solutions for complex challenges.
  • Customization: Every project is tailored to meet specific research goals, including antibody type, species, and application requirements.
  • State-of-the-Art Platforms: We utilize the latest technologies for antigen preparation, screening, and engineering.
  • Dedicated Support: Our team of experts provides full-cycle support, from consultation to delivery of the final product.

FAQs

What quality control measures are in place for A17L antibody development?

Quality is at the core of all our services. Creative Biolabs applys rigorous quality control measures at each stage of the A17L antibody development process. These include:

  • Antigen Verification: Confirmation of antigen purity and functionality prior to immunization.
  • Screening Standards: Multiple screening platforms, such as ELISA, flow cytometry, and Western blot, ensure high specificity and binding affinity.
  • Final Validation: Functional assays, including cell-based assays or neutralization studies (if applicable), are conducted to confirm performance.

What animal models are available for immunization in A17L antibody development?

Creative Biolabs offers a broad range of animal models for immunization, including mice, rats, rabbits, and other species, based on your specific project needs. Our team provides guidance on the most suitable model to achieve your research goals, taking into account factors like antibody type, expected yield, and downstream applications.

Can Creative Biolabs support antibody conjugation for specialized applications?

Absolutely. Creative Biolabs offers antibody conjugation services to enable the use of A17L antibodies in specific applications such as flow cytometry, immunofluorescence, or ELISA. Common conjugations include:

  • Fluorescent dyes.
  • Enzymes (e.g., HRP, alkaline phosphatase).
  • Biotin or other small-molecule tags.

Our team ensures that conjugation processes maintain antibody integrity and performance, optimizing them for your intended use.

Resources

We DO NOT PROVIDE ANY PRODUCTS OR SERVICES DIRECTLY TO PATIENTS. All of our products are for Research Use Only (RUO), NOT intended for diagnostic, therapeutic, or clinical use.