Customer Demand & Project Design
We begin with in-depth discussions to understand your specific research objectives, tailoring the experimental design precisely to your needs.
We DO NOT PROVIDE ANY PRODUCTS OR SERVICES DIRECTLY TO PATIENTS. All of our products are for Research Use Only (RUO), NOT intended for diagnostic, therapeutic, or clinical use.
The rapid spread of monkeypox highlights an urgent need for advanced therapeutic solutions. Based on Creative Biolabs' extensive experience and advanced platforms, we now proudly offer specialized anti-monkeypox drug discovery services, specifically targeting host cellular factors, to clients worldwide.
The Monkeypox virus (MPXV), a large double-stranded DNA virus, presents a significant and escalating threat to global public health. While conventional antiviral strategies often focus on directly inhibiting viral components, Creative Biolabs champions a groundbreaking approach: targeting the host cellular machinery indispensable for MPXV's lifecycle. This innovative strategy offers a robust defense against viral adaptation, effectively circumventing drug resistance issues commonly associated with direct viral inhibitors, thereby promising more durable and effective antiviral agents.
Automated platforms efficiently screen vast compound libraries (small molecules, biologics) to rapidly identify drug candidates modulating specific cellular targets, yielding promising anti-Mpox hits.
Advanced cellular assays precisely quantify antiviral effects: virus entry inhibition, virus replication inhibition (qPCR, Western Blot, fluorescent reporter), and virus assembly/release inhibition. Concurrently, cell survival and toxicity tests ensure compound safety.
We conduct rigorous biophysical and biochemical analyses to confirm direct interaction and functional impact. Techniques like surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) assess compound binding affinity, while enzyme activity inhibition experiments precisely measure target protein modulation.
Building upon successful screening results, our expert medicinal chemists offer bespoke lead compound optimization and active molecule synthesis services. This iterative process refines selectivity for cellular targets and enhances pharmacokinetic/pharmacodynamic (PK/PD) properties, ensuring optimal drug-likeness.
Creative Biolabs offers expertise in selecting the most appropriate animal models for MPXV infection, including well-characterized mouse models (immunodeficient, genetically engineered) for pathogenesis and efficacy studies. When applicable and ethically qualified, highly translational non-human primate models are also utilized. Each model is chosen for its specific characteristics to provide robust, reliable data.
Our team offers unparalleled flexibility in designing optimal drug administration routes (oral, injection) tailored to compounds and targets. We meticulously craft experimental protocols to maximize data quality and translational relevance, ensuring robust in vivo studies.
We begin with in-depth discussions to understand your specific research objectives, tailoring the experimental design precisely to your needs.
Upon agreement, a clear contract outlines project details and deliverables, formalizing our partnership and promptly initiating the project.
Our dedicated teams meticulously execute the plan, encompassing HTS, lead compound synthesis, and rigorous in vitro and in vivo verification studies.
Data are continuously collected, rigorously analyzed, and compiled into professional reports, providing clear insights into project progress and findings.
Final results, including raw data and comprehensive reports, are delivered promptly. We remain committed to your success, offering ongoing consultation and scientific support.
Click the button to contact us for service details and a custom quote.
The MPXV masterfully exploits numerous host cellular mechanisms to facilitate its invasion, replication, assembly, and release. This includes hijacking host transcription and translation machinery, manipulating membrane trafficking pathways for replication factory formation and viral egress, and actively subverting host immune responses by targeting key cellular signaling pathways. The virus also redirects host nutrient acquisition pathways to support its high metabolic demands.
Fig.1 Replication of MPXV in the host cytoplasm.1
Our drug discovery service precisely identifies and targets these critical cellular vulnerabilities. For instance, we focus on inhibiting host receptors essential for virus entry, interfering with host enzymes indispensable for viral replication, or blocking cellular pathways crucial for virus budding and release. By disrupting these specific host-virus interactions, Creative Biolabs effectively inhibits viral infection and propagation.
In-Depth Cell Biology and Virology Research Expertise
Our expert team deeply understands host-virus interactions, ensuring robust, innovative drug discovery.
Comprehensive Integrated Platform
We offer a seamless, one-stop solution from screening to verification, streamlining your R&D.
Customized and Flexible Services
Recognizing unique project needs, we provide flexible experimental designs and reports, tailored to your objectives.
High Throughput and High Efficiency
Advanced automated platforms and optimized workflows enable rapid, efficient drug screening, accelerating candidate identification.
Competitive Pricing
We provide exceptional value through competitively priced services, ensuring cutting-edge capabilities without compromising quality.
Host cellular proteins are under far less evolutionary pressure to mutate in response to drug exposure than rapidly evolving viral proteins. Viruses can quickly develop mutations that render direct antiviral drugs ineffective. By targeting essential host pathways, we exploit vulnerabilities that the virus cannot easily bypass without severely compromising its own replication, thereby building a higher barrier to resistance.
We have access to and utilize a diverse array of compound libraries for HTS, including extensive proprietary collections developed over years of research, as well as a wide selection of commercially available small molecule and biologic libraries. This broad access maximizes the chemical diversity explored, significantly increasing the likelihood of discovering novel chemical scaffolds.
Target validation is a critical step in our process. We employ multiple orthogonal methods, including siRNA knockdown, specific small molecule inhibitors, and genetic rescue experiments in cell culture models. Crucially, the essentiality of the target is further confirmed in relevant in vivo animal models of poxvirus infection to ensure translational relevance and clinical applicability.
Safety and pharmacokinetic profiling are integrated early and rigorously into our preclinical development pipeline. We conduct comprehensive ADME (Absorption, Distribution, Metabolism, Excretion) and toxicology assessments using a battery of in vitro and in vivo assays. This meticulous evaluation ensures that only compounds with favorable drug-like properties and acceptable safety profiles progress to further development.
Yes, absolutely. Our experienced medicinal chemistry team specializes in lead optimization. If you have existing lead compounds, we can apply rational design principles, structure-activity relationship (SAR) studies, and advanced synthetic chemistry techniques to improve their potency, selectivity, pharmacokinetic properties, and overall drug-likeness against the identified cellular targets.
Our commitment to your success extends beyond the delivery of final results. We offer ongoing scientific consultation and follow-up support to address any questions you may have, discuss future research directions, or assist with data interpretation for publications or regulatory submissions. We aim to be a long-term partner in your drug discovery endeavors.
Creative Biolabs is a leading service provider that focuses on anti-monkeypox drug development. We can assist you in designing the best research outline customized to meet the requirements of clients’ programs. If you are interested in our services and products, please do not hesitate to contact us for more details.
Reference
We DO NOT PROVIDE ANY PRODUCTS OR SERVICES DIRECTLY TO PATIENTS. All of our products are for Research Use Only (RUO), NOT intended for diagnostic, therapeutic, or clinical use.