We DO NOT PROVIDE ANY PRODUCTS OR SERVICES DIRECTLY TO PATIENTS. All of our products are for Research Use Only (RUO), NOT intended for diagnostic, therapeutic, or clinical use.
Creative Biolabs provides a specialized Monkeypox E9L antibody development service tailored to researchers and institutions focused on studying monkeypox virus (MPXV) and its mechanisms. E9L, a viral protein from MPXV, plays a crucial role in the virus's immune evasion strategies, making it a target for antibody-based studies. Creative Biolabs is well-equipped to assist in the development of high-quality, specific antibodies against E9L, contributing to the advancement of both basic and applied virology research.
At Creative Biolabs, we offer a comprehensive suite of services for the generation of highly specific antibodies against the E9L protein of monkeypox virus. Our services are tailored to meet the unique needs of our clients, whether they are engaged in basic research, diagnostic development, or vaccine design.
Our custom antibody development service starts with the design and synthesis of E9L antigens, which are key to inducing a strong immune response in animals. Using these antigens, we immunize animals (such as mice, rabbits, or goats) to generate polyclonal antibodies. Alternatively, we offer monoclonal antibody development services through hybridoma technology, ensuring high specificity and affinity for the E9L target.
For clients requiring highly specific antibodies, our phage display library service offers a cutting-edge solution. Using this technology, we can generate a diverse library of antibodies against the E9L protein, followed by the selection of high-affinity binders through a series of stringent screening procedures.
We provide extensive characterization and validation of the antibodies generated through various methods such as enzyme-linked immunosorbent assays (ELISA), western blotting, immunohistochemistry (IHC), and flow cytometry. These assays ensure that the antibodies have the desired specificity and sensitivity for the E9L protein.
Once the antibodies are generated, we offer isotyping to determine the subclass of the antibodies (IgG, IgM, IgA, etc.) and affinity maturation services to enhance the binding strength and specificity of the antibodies. These services ensure that the antibodies are optimized for a range of applications, including high-sensitivity assays and immune-based therapeutic studies.
We also offer bulk production services for clients requiring large quantities of high-quality antibodies. This service ensures a consistent supply of antibodies for large-scale research projects, diagnostic kit development, or even potential therapeutic applications. We adhere to stringent quality control standards to ensure that each batch meets the highest standards of purity and activity.
The E9L protein of monkeypox virus plays a critical role in the virus's ability to evade the host immune response. This protein is involved in inhibiting the host's interferon signaling pathways, which are essential for the antiviral immune response. By disrupting these pathways, E9L enables the virus to replicate more efficiently within the host, thus contributing to the pathogenesis of monkeypox.
Additionally, E9L has been shown to interact with various host cell machinery to block apoptosis, ensuring the survival of infected cells long enough for the virus to complete its replication cycle. This immune evasion strategy makes E9L a valuable target for antibody development, as neutralizing these interactions could potentially hinder the virus's ability to spread and persist in the host.
| Cat# | Product Name | Target | Antibody Isotype | Species Reactivity | Applications |
|---|---|---|---|---|---|
| MPYF-1122-KX1642 | Anti-Squirrel Parapoxvirus E9L Monoclonal Antibody (MP-K2442) (Mouse IgG) | E9L | Mouse IgG | Squirrel Parapoxvirus | WB (Other applications need to be tested) |
| MPYF-1022-KX1573 | Anti-Variola (Smallpox) Virus E9L Monoclonal Antibody (MP-K1507) (Mouse IgG) | E9L | Mouse IgG | Variola (Smallpox) Virus | WB (Other applications need to be tested) |
| MPYF-1022-KX1567 | Anti-Vaccinia Virus (Smallpox Vaccine) E9L Monoclonal Antibody (MP-K1301) (Mouse IgG) | E9L | Mouse IgG | Vaccinia Virus (Smallpox Vaccine) | WB (Other applications need to be tested) |
| Cat# | Product Name | Species | Expression System | Target Protein | Protein Length |
|---|---|---|---|---|---|
| MPYF-1022-KX778 | Magic™ Squirrel Parapoxvirus (Red squirrel UK) E9L Recombinant Protein | Squirrel Parapoxvirus | Based on specific requirements | E9L | Full length |
| MPYF-0922-KX708 | Magic™ Variola (Smallpox) Virus (India-1967, Ind3) E9L Recombinant Protein | Variola (Smallpox) Virus | Based on specific requirements | E9L | Full length |
| MPYF-0922-KX502 | Magic™ Vaccinia Virus (Smallpox Vaccine) (Western Reserve) E9L Recombinant Protein | Vaccinia Virus (Smallpox Vaccine) | Based on specific requirements | E9L | Full length |
Creative Biolabs utilizes a variety of advanced platforms and technologies to support the development of high-quality antibodies against the E9L protein:
For generating highly specific and high-affinity monoclonal antibodies.
For the generation of robust monoclonal antibodies from immune cells.
To produce antibodies with defined specificity and affinity in a controlled, reproducible manner.
Customized for generating a strong immune response in a variety of animal models.
Antibodies against the E9L protein of monkeypox virus can be employed in various research and diagnostic applications:
Creative Biolabs stands out as a leading provider of high-quality, tailored antibody development services for researchers working on monkeypox virus. Here are several reasons to choose our services:
Creative Biolabs utilizes various animal models, including mice, rabbits, and goats, based on the specific antibody type (polyclonal or monoclonal) and immune response requirements to produce highly specific E9L antibodies.
Rigorous quality control includes monitoring immune responses, titration assays, and confirming antibody specificity via ELISA and western blot. Each batch undergoes thorough testing for purity, specificity, and functional activity before delivery.
Yes, E9L antibodies can be used in vivo in animal models to study immune evasion or viral pathogenesis. Creative Biolabs provides customized formulations for specific in vivo applications, ensuring safety and efficacy.
We DO NOT PROVIDE ANY PRODUCTS OR SERVICES DIRECTLY TO PATIENTS. All of our products are for Research Use Only (RUO), NOT intended for diagnostic, therapeutic, or clinical use.