Sheeppox Virus

Poxviruses are a group of DNA viruses that can infect many domestic animals, wild animals, and humans. With the global outbreak of monkeypox, viruses similar to monkeypox viruses such as the sheeppox virus (SPV) have made their way into the spotlight. To prevent economic losses in the livestock industry and the spread of zoonotic diseases caused by SPV, Creative Biolabs provides reliable viral products, innovative platforms, and one-stop anti-virus drug discovery solutions. Our services enable global customers to understand the properties of viruses and their infectious virus lifecycles, as well as to promote the development of antiviral drugs.

Fig.1 Sheep.

Background of Sheeppox Virus

The sheeppox virus is a poxvirus belonging to the genus Capripoxvirus. The natural hosts of SPV are domesticated and wild sheep. The younger and older populations of the sheep and lactating sheep are more susceptible to SPV. SPV infection causes a devastating viral systemic disease that is defined by constant fever, widespread skin pox lesions, vesicles on non-wool skin, generalized papules or nodules, internal lesions of the respiratory and gastrointestinal mucosa, and ultimately leads to death. Its morbidity is up to 70%-100% and the mortality rate is in the range of 10%-85%. In most cases, the disease is transmitted by direct contact, but it can also be transmitted by indirect contact with infected objects, mechanical insects, aerosols, and nasal secretions. The SPV has been found to be endemic in areas where large-scale intensive sheep are farmed including Asia, the Middle East, Africa, and India. Since the sheep are economically valuable livestock whose main economic value is wool production and milk yield, the SPV has caused severe economic losses in the livestock industry. Only two instances of zoonotic transmission that only cause a mild localized cutaneous response have been documented. Specific agents and vaccines for the virus need to be further developed.

Fig.2 Clinical sign of Malignant type of sheeppox. (Hurisa, 2018)

Sheeppox Virus Services at Creative Biolabs

Creative Biolabs has years of experience to provide multiple SPV products and drug discovery solutions. Prevention and diagnosis of SPV infection are generally dependent on polymerase chain reaction (PCR). We offer a wide range of SPV-related PCR primers and probes. In order to meet research and development requirements, we also provide recombinant proteins and peptides, antibodies, and cell lines for viral studies, and other viral products. Our one-stop solutions for anti-SPV drug discovery are established based on precocious technologies and reliable in vitro and in vivo platforms, which enables our clients to develop agents targeting the critical steps of the infectious virus lifecycle. If you have the intention to learn more about sheeppox virus products and drug discovery solutions, please feel free to contact us. To speed up your program, our experienced professionals will provide the finest solution for you as soon as possible.

Reference

1. Hurisa, T. T.; et al. A Review on Sheeppox and Goatpox: Insight of Epidemiology, Diagnosis, Treatment and Control Measures in Ethiopia. Journal of Infectious Diseases and Epidemiology. 2018, 4(3): 2474-3658.