We DO NOT PROVIDE ANY PRODUCTS OR SERVICES DIRECTLY TO PATIENTS. All of our products are for Research Use Only (RUO), NOT intended for diagnostic, therapeutic, or clinical use.
Creative Biolabs offers specialized services for the development of antibodies against key viral proteins involved in the monkeypox virus (MPXV) lifecycle. Among these proteins, K1L has emerged as an intriguing target due to its critical role in immune evasion. With years of experience and cutting-edge technologies, Creative Biolabs is well-positioned to provide high-quality antibody development services for K1L, helping to support research into the molecular mechanisms of monkeypox and advancing the study of potential diagnostic or therapeutic solutions.
K1L is a viral protein expressed by the monkeypox virus (MPXV), which is part of the family Poxviridae. The protein plays a pivotal role in MPXV’s ability to evade the host immune system, particularly by interfering with the host’s type I interferon signaling pathway. This function of K1L is essential for the virus to establish an infection, as it aids in the inhibition of the host’s antiviral immune response. As researchers continue to study MPXV, the K1L protein has become a crucial target for the development of antibodies aimed at understanding the virus's molecular interactions and mechanisms of pathogenesis.
Creative Biolabs provides comprehensive, tailor-made services for the development of specific antibodies against the K1L protein of the monkeypox virus. Our approach is highly customizable to meet the unique needs of your research or diagnostic applications. The following key services are included in our K1L-specific antibody development program:
We generate high-quality synthetic peptides or full-length K1L proteins, ensuring that they represent the viral protein’s most immunogenic epitopes. This is the first critical step in developing antibodies that can accurately target the K1L protein in various experimental settings.
Based on the antigen, we employ multiple animal species (such as rabbits, mice, and goats) to create polyclonal antibodies. Our immunization strategies ensure the development of highly specific antibodies capable of detecting K1L across a range of conditions.
For more defined, single-epitope targeting, we offer monoclonal antibody development. Our hybridoma technology allows us to produce monoclonal antibodies that specifically bind to K1L, enabling their use in various research applications such as Western blotting, immunohistochemistry, and flow cytometry.
To ensure the highest standards, all antibodies are rigorously characterized for specificity, affinity, and cross-reactivity. We employ techniques such as ELISA, immunofluorescence, and Western blot analysis to validate the performance of the developed antibodies.
Depending on the research needs, we can also offer services to humanize monoclonal antibodies or produce recombinant versions for further applications. Creative Biolabs’ flexibility ensures that you receive the exact antibody development service suited for your specific project goals.
The primary mechanism of action (MoA) of K1L in monkeypox involves immune evasion, specifically by inhibiting type I interferon (IFN-I) signaling. This interferon pathway is a key component of the innate immune response and is crucial for the defense against viral infections. By blocking this pathway, K1L allows MPXV to persist in the host without triggering a robust antiviral immune response.
In addition to its interference with interferon signaling, K1L is known to interact with several host cell proteins that are involved in immune recognition, further enhancing the virus’s ability to evade detection and clearance by the immune system. This makes K1L a valuable target for researchers looking to dissect the viral immune evasion strategies and potentially develop diagnostic or experimental tools for detecting MPXV infections.
| Cat# | Product Name | Target | Antibody Isotype | Species Reactivity | Applications |
|---|---|---|---|---|---|
| MPVF-1022-KX1562 | Anti-Variola (Smallpox) Virus K1L Monoclonal Antibody (MP-K1496) (Mouse IgG) | K1L | Mouse IgG | Variola (Smallpox) Virus | WB (Other applications need to be tested.) |
| MPVF-1022-KX1344 | Anti-Vaccinia Virus (Smallpox Vaccine) K1L Monoclonal Antibody (MP-K1278) (Mouse IgG) | K1L | Mouse IgG | Vaccinia Virus (Smallpox Vaccine) | WB (Other applications need to be tested.) |
| Cat# | Product Name | Species | Expression System | Target Protein | Protein Length |
|---|---|---|---|---|---|
| MPVF-0922-KX479 | Magic™ Vaccinia Virus (Smallpox Vaccine) (Western Reserve) K1L Recombinant Protein | Vaccinia Virus (Smallpox Vaccine) | Based on specific requirements | K1L | Full length |
| MPVF-0922-KX697 | Magic™ Variola (Smallpox) Virus (India-1967, Ind5) K1L Recombinant Protein | Variola (Smallpox) Virus | Based on specific requirements | K1L | Full length |
Creative Biolabs leverages state-of-the-art platforms and technologies to ensure the success of K1L antibody development services:
We utilize advanced recombinant expression systems in bacterial, yeast, and mammalian cells to produce high-quality K1L protein and its variants for use in antibody generation.
Our industry-leading hybridoma platform is used to produce monoclonal antibodies, ensuring highly specific and reproducible results.
We offer the synthesis of custom peptides derived from the K1L protein, which can be used for immunization or screening purposes.
We use ELISA, flow cytometry, and immunohistochemistry, to validate the specificity and functionality of antibodies developed against K1L.
The K1L antibodies developed by Creative Biolabs have numerous potential applications, including:
Creative Biolabs stands out for its expertise and dedication to providing high-quality services in the development of K1L antibodies. Here are some reasons why you should choose our services:
Yes, Creative Biolabs offers custom antibody development services tailored to the specific needs of your research, ensuring that the antibodies developed are suitable for your experiments.
Yes, the K1L antibodies developed by Creative Biolabs are suitable for both in vitro and in vivo applications. Whether you are performing cell-based assays, immunohistochemistry, or animal model studies, our antibodies are validated to work across a variety of experimental settings.
Yes, the K1L antibodies are suitable for use in multiplex assays, such as multiplex ELISA or bead-based assays, where multiple analytes are detected simultaneously. Creative Biolabs ensures that all antibodies undergo extensive testing to ensure minimal cross-reactivity and high specificity.
We DO NOT PROVIDE ANY PRODUCTS OR SERVICES DIRECTLY TO PATIENTS. All of our products are for Research Use Only (RUO), NOT intended for diagnostic, therapeutic, or clinical use.