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Tanapox, Yaba-Like Disease Virus
As a leading platform with in-depth knowledge of life science, Creative Biolabs provides dependable viral products as well as innovative platforms and technologies for the development of anti-virus agents. Viruses that are similar to the monkeypox virus have been coming into our sights. The Tanapox virus and Yaba-like disease virus (YLDV) belonging to poxvirus may also infect humans. It is necessary to understand the features of the virus and its infectious viral lifecycle in order to prevent the spread of viruses. Longitudinal studies of these viruses, from mechanistic to clinical, will be simplified by Creative Biolabs' extensive offerings.
Background of Tanapox and Yana-Like Disease Virus
Yaba-like disease virus is intimately associated with the Tanapox virus. Both Tanapox virus and YLDV are DNA poxviruses belonging to the genus of Yatapoxvirus, which has similar size, shape, and ultrastructure. Although monkeys and baboons are natural hosts of these viruses, they also infect humans or other primates. Tanapox virus affects almost exclusively the epidermis in either monkeys or humans, whereas the lesions of YLDV are proliferative and invade mesodermal cells. The pathology of both viruses resembles vaccinia. Recovered monkeys from Tanapox and YLDV infections have cross-immunity and serological cross-reactions exist between the viruses.
Tanapox virus was first isolated among human individuals in the flood plain of the Tana River in Kenya around the 1960s and was therefore considered to be a zoonotic disease. The Tanapox infections occur widely throughout tropical Africa, particularly in people working or playing near the sewage, tropical forests, and contaminated rivers. Most of the infected people present mild fever for three or four days, severe headaches and backaches, small nodule that develops into popular, and appearance of skin lesion. The skin lesions are generally solitary and pruritic, leaving scars after healing. Tanapox virus induces degeneration of the infected cells and intense granularity. It is speculated that Tanapox viruses carried by monkeys or baboons may be transmitted to humans through mechanical vectors such as infected arthropods. The smallpox vaccination would not be expected to be protective for Tanapox.
Fig.1 Electron micrograph of negatively stained highly purified Tanapox virus. (Essani, 2011)
Yana-like disease virus
YLDV was first found from epidemic infection in macacus monkeys in California, Oregon, and Texas in 1966. The virus induces Yaba-like disease, Yaba-related disease, and benign epidermal monkey pox. BS-C-1 is a cell line used to study YLDV infection, which exhibits epithelial morphology isolated from the kidney of an African green monkey. In contrast to Tanapox infection, YLDV infections in BS-C-1 cells generate small heaped up tumor-like masses. YLDV infection is also considered to be a zoonotic disease.
Fig.2 Electron microscopic photo of intracellular YLD virus particles in various stages of maturation. (Hu, 2001)
Tanapox and Yaba-like Disease Virus Services at Creative Biolabs
Creative Biolabs provides a comprehensive range of services related to both Tanapox virus and YLDV, including polymerase chain reaction (PCR) related products for virus detection, recombinant proteins and peptides, antibodies, and cell lines for viral studies, and other viral products. In addition, anti-virus agent development solutions that target the entrance, replication, proteolytic processing, and particle egress steps of Tanapox and YLDV are available at Creative Biolabs. Our advanced technologies, in vitro and in vivo platforms, and efficient anti-virus agent discovery solutions facilitate your research and development progress. To learn more about the Tanapox virus and Yaba-like disease virus, please don’t hesitate to contact us.
Hu, Y.; et al. Yaba-like disease virus: an alternative replicating poxvirus vector for cancer gene therapy. Journal of Virology. 2001, 75(21): 10300-10308.
Essani, K.; et al. Yatapoxvirus. In The Springer index of viruses. 2001.