Goatpox Virus

Poxviruses can infect wild animals, livestock, and humans, resulting in cutaneous and systemic diseases and, in severe cases, death. Along with the global outbreak of monkeypox, viruses analogous to monkeypox virus, such as the goatpox virus (GPV), have become a focus of concern. As a leading server in the field of life science, Creative Biolabs provides reliable viral products and one-stop solutions for antiviral drug discovery. Our services promote the mechanical studies of viruses and the development of antiviral drugs, which play an important role in preventing economic losses in the livestock industry caused by GPV.

Fig.1 Goat.

Background of Goatpox Virus

The goatpox virus is a contagious poxvirus belonging to the genus Capripoxvirus. Goat populations located in Asia, Europe, the Middle East, and Africa are natural hosts of GPV. Goatpox is not considered to be a zoonotic disease. The GPV is primarily transmitted by direct contact with infected goats, or indirect contact with contaminated objects. Indirect mechanical transmission by insects, aerosols, inhalation, intradermal, or subcutaneous inoculation can also lead to GPV infection. The clinical symptoms of the GPV infection initially present as fever, salivation, nasal discharge, and conjunctivitis. Skin lesions including vesicles, pustules, and then scabs emerge a few days after infection. The infected goats may get mastitis when the orifices of the teats get infected. Internal lesions in the lungs and gastrointestinal mucosa result in respiratory distress and anorexia. The morbidity of goatpox is in the range of 70%-90% and the mortality rate is up to 5%-10%. The mortality rate of susceptible animals including lactating goats approaches 100%. As goats are economically important animals for the livestock industry, their meat production and milk production are important sources. GPV infection seriously affects the economic value of goats. Therefore, it’s urgent to develop vaccines and effective drugs against GPV.

Fig.2 Lesions following experimental infection of goats with a Vietnamese goatpox virus isolate. (Hamdi, 2021)

Goatpox Virus Services at Creative Biolabs

Having years of expertise, Creative Biolabs offers a variety of goatpox virus products and anti-GPV drug discovery solutions. Our all-inclusive antiviral drug discovery services are built on cutting-edge technology and dependable in vitro and in vivo platforms, allowing our clients to explore drugs that specifically target important stages of the infectious viral lifecycle. Polymerase chain reaction (PCR) is typically used for GPV detection and prevention. We provide a comprehensive selection of PCR primers and probes for the GPV. We also offer recombinant proteins and peptides, antibodies, cell lines for viral research, and other viral products to fulfill research and development purposes. Our professionals offer the best solution for you to expedite your program. Please don’t hesitate to contact us if you're interested in learning more about goatpox products and drug development solutions.

Reference

1. Hamdi, J.; et al. Experimental infection of indigenous North African goats with goatpox virus. Acta Veterinaria Scandinavica. 2021, 63(1): 1-9.