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Overview of Canarypox Virus
Canarypox virus (CNPV), an avipoxvirus, is the causative agent of canarypox, a disease of wild and captive birds that can cause significant damage. Canarypox virus is a member of the Poxviridae family. There are other nine well-known species in the poxviridae family, including: fowlpox virus, Juncopox virus, Mynahpox virus, Psittacinepox virus, Sparrowpox virus, Starlingpox virus, Pigeonpox virus, Turkeypox virus, and Quailpox virus.
CNPV is an infectious disease. CNPV can induce cellular, humoral and mucosal immune responses in the host after infection, and can be developed into a candidate vaccine vector after transformation, which can express various proteins of viruses and parasites. Therefore, the development of recombinant CNPV vector vaccine for immune prevention has the advantages of significant economic significance.
Hot Topcis of Canarypox Virus
Live canarypox virus can express the rabies virus glycoprotein, which is licensed in the United States as a parenteral monovalent vaccine for cats and the feline panleukopenia virus, feline parvovirus and feline calicivirus vaccines included in the product rabies combination vaccine for cats.
Figure 1. The canarypox vector (ALVAC) is a live attenuated virus with a large capacity to incorporate foreign genes.(Pathogens, 2016)
Canarypox viruses (CNPV) are excellent candidates for the development of recombinant vector vaccines because of their ability to induce protective immune responses and their ability to replicate in mammalian cells (safety).
Poxvirus vectors serve as vaccine candidates for multiple pathogens and cancers, but their innate stimulatory properties remain poor. Here, we show that the canarypox virus-based vector ALVAC induces distinct systemic pro-inflammatory and antiviral cytokines and chemotaxis following vaccination in rhesus monkeys compared with the vaccinia virus-based vectors MVA and NYVAC factor level.
Visual Examples of Canarypox Virus
All of the birds showed thickened eye lid and scablike lesions on skin or feet.
Figure 2. Scab-like lesions on skin (a) and feet (b) (left). Thickened eye lids of affected birds (right).(Journal of Applied Animal Research, 2018)
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Paillot R, Rash N L, Garrett D, et al. How to meet the last OIE expert surveillance panel recommendations on equine influenza (EI) vaccine composition: A review of the process required for the recombinant canarypox-based EI vaccine[J]. Pathogens, 2016, 5(4): 64.