We DO NOT PROVIDE ANY PRODUCTS OR SERVICES DIRECTLY TO PATIENTS. All of our products are for Research Use Only (RUO), NOT intended for diagnostic, therapeutic, or clinical use.
Monkeypox, a viral disease caused by the monkeypox virus (MPXV), has recently garnered global attention due to outbreaks outside its endemic regions. The H3L protein, a major protein of the monkeypox virus, plays a crucial role in the viral lifecycle. Creative Biolabs offers comprehensive antibody development services, including the generation of highly specific antibodies against H3L, aimed at advancing research and diagnostic applications. The H3L protein is involved in the immune evasion mechanisms of MPXV, making it an essential target for antibody development. Understanding its structure and function is key to creating effective detection and neutralization strategies for the virus.
Creative Biolabs offers a range of tailored services for the development of high-affinity, high-specificity antibodies against the H3L protein of the monkeypox virus. Our expert team utilizes cutting-edge technologies to generate monoclonal and polyclonal antibodies that can be used in a variety of applications, including diagnostic assays, research tools, and potential antiviral strategies.
Our H3L antibody development services include:
The first step in antibody development involves the creation of highly immunogenic antigen constructs, optimized for the production of H3L-specific antibodies.
We use multiple animal models to immunize with H3L protein or its key epitopes to induce a robust immune response, followed by screening for high-affinity antibodies.
Our hybridoma platform allows for the generation of monoclonal antibodies that are stable, reproducible, and can be produced in large quantities. These monoclonal antibodies are screened for their specificity and ability to neutralize the virus.
We also offer recombinant antibody development, utilizing mammalian or bacterial expression systems to produce antibodies with high specificity and activity.
Once antibodies are developed, we conduct comprehensive validation using ELISA, Western blotting, flow cytometry, and neutralization assays to assess their binding affinity, specificity, and neutralizing potential.
Our services are designed to meet the specific needs of our clients, whether for basic research, assay development, or the advancement of novel therapeutic strategies. Creative Biolabs' extensive experience in antibody development ensures that the antibodies generated are optimized for performance in a wide range of experimental conditions.
The H3L protein functions as a viral immune modulator, effectively interfering with the host's immune response. By inhibiting the host's interferon response, it helps the virus evade early immune detection, thus facilitating viral replication. This mechanism of action significantly contributes to the persistence of the virus in the host organism.
H3L's ability to block the antiviral actions of interferon renders it a critical target for antibody development. Neutralizing antibodies that bind to H3L can potentially prevent the virus from escaping immune surveillance, offering a promising avenue for therapeutic research and diagnostic purposes.
| Cat# | Product Name | Target | Antibody Isotype | Species Reactivity | Applications |
|---|---|---|---|---|---|
| MPYF-1122-KX1664 | Anti-Squirrel Parapoxvirus H3L Monoclonal Antibody (MP-K2464) (Mouse IgG) | H3L | Mouse IgG | Squirrel Parapoxvirus | WB (Other applications need to be tested.) |
| MPYF-1022-KX1398 | Anti-Vaccinia Virus (Smallpox Vaccine) H3L Monoclonal Antibody (MP-K1332) (Mouse IgG) | H3L | Mouse IgG | Vaccinia Virus (Smallpox Vaccine) | WB (Other applications need to be tested.) |
| MPYF-0822-YF24 | Anti-Monkeypox Virus H3L Monoclonal Antibody (MP-X24) (Mouse IgG2a, kappa) | H3L | Mouse IgG2a, kappa | Monkeypox Virus | Neut; ELISA |
| MPYF-0822-YF178 | Anti-Monkeypox Virus H3L Monoclonal Antibody (MP-W143) (Mouse IgG) | H3L | Mouse IgG | Monkeypox Virus | WB (Other applications need to be tested.) |
| MPYF-0822-YF39 | Anti-Monkeypox Virus H3L Monoclonal Antibody (MP-X39) (Mouse IgG2a, kappa) | H3L | Mouse IgG2a, kappa | Monkeypox Virus | ELISA |
| Cat# | Product Name | Usage |
|---|---|---|
| MPYF-0722-KX1715 | Monkeypox Virus H3L IgM ELISA Kit (RUO) | RUO |
| MPYF-0722-KX1713 | Monkeypox Virus H3L IgA ELISA Kit (RUO) | RUO |
| MPYF-0722-KX1714 | Monkeypox Virus H3L IgG ELISA Kit (RUO) | RUO |
| Cat# | Product Name | Species | Target |
|---|---|---|---|
| MPYF-0722-KX1589 | Monkeypox virus, H3L-R | Monkeypox virus | H3L |
| MPYF-0722-KX1398 | Monkeypox virus, H3L-F | Monkeypox virus | H3L |
| Cat# | Product Name | Species | Target |
|---|---|---|---|
| MPYF-0722-KX1207 | Magic™ Monkeypox virus H3L Expression Plasmid | Monkeypox virus | H3L |
Creative Biolabs leverages advanced platforms and technologies to ensure the successful development of high-quality H3L antibodies. These include:
A powerful method for selecting high-affinity antibodies from large synthetic libraries, ensuring that only the most effective candidates are chosen for further development.
Employed for antibody gene sequencing and optimization, ensuring the highest levels of precision in antibody development.
For the production of fully glycosylated antibodies, ensuring their functional relevance and stability in biological assays.
Allows for rapid identification and selection of the best antibody candidates from large numbers of potential leads.
H3L-specific antibodies have multiple applications in the study of monkeypox and viral immunology. These antibodies can be employed in diagnostic tests, including immunoassays such as ELISA and immunohistochemistry (IHC), enabling the detection of the virus in clinical and research samples. Additionally, neutralizing antibodies targeting H3L hold potential in preclinical research as part of vaccine development or antiviral therapeutic strategies.
Creative Biolabs is a leading provider of antibody development services, with extensive expertise in the production of high-quality antibodies for viral research. Key reasons to choose us include:
Creative Biolabs' antibodies are extensively validated for use in animal models, including mouse, rat, and non-human primate models. They can be employed for research involving virus detection, immune response studies, and other immunological investigations.
Yes, Creative Biolabs offers both monoclonal and polyclonal antibody development services, depending on your specific research needs.
Yes, Creative Biolabs offers comprehensive assay development services using H3L antibodies. Whether you need to develop an ELISA, Western blot, or flow cytometry assay, we provide the expertise and resources to ensure the antibodies perform effectively in your assay systems.
Yes, Creative Biolabs offers custom antibody conjugation services. We can conjugate H3L-specific antibodies to a variety of labels, such as fluorophores, enzymes, or magnetic beads, to suit your application in immunoassays or other detection platforms.
We DO NOT PROVIDE ANY PRODUCTS OR SERVICES DIRECTLY TO PATIENTS. All of our products are for Research Use Only (RUO), NOT intended for diagnostic, therapeutic, or clinical use.