We DO NOT PROVIDE ANY PRODUCTS OR SERVICES DIRECTLY TO PATIENTS. All of our products are for Research Use Only (RUO), NOT intended for diagnostic, therapeutic, or clinical use.
Creative Biolabs offers specialized services in the development of B8R-specific antibodies for research into Monkeypox, a zoonotic disease caused by the monkeypox virus (MPXV). These antibodies are critical for studying the virus's mechanisms, diagnosing infections, and advancing scientific knowledge in the realm of immunology and viral pathogenesis.
The B8R protein is one of the key viral proteins involved in MPXV pathogenesis. It plays an important role in immune evasion by inhibiting the host's innate immune response. Understanding the function and properties of B8R is crucial for developing specific diagnostic tools and enhancing our understanding of the virus's molecular mechanisms. Creative Biolabs provides custom services for the generation of high-affinity antibodies targeting B8R, facilitating the study of its role in monkeypox virus infection.
Creative Biolabs specializes in the development of high-quality, specific antibodies targeting the B8R protein of monkeypox virus. Our services are designed to support research projects at every stage, from initial antigen design and immunization to the generation of monoclonal and polyclonal antibodies. We ensure the production of high-affinity, well-characterized antibodies tailored to specific research needs.
Creative Biolabs offers monoclonal antibody (mAb) development services against the B8R protein. Our hybridoma technology allows for the generation of monoclonal antibodies with high specificity and reproducibility. We employ a rigorous screening process to identify the best candidates, ensuring that the antibodies are highly sensitive and effective for various applications, including ELISA, Western blotting, and immunohistochemistry.
Polyclonal antibodies can recognize multiple epitopes on the B8R protein, making them ideal for applications such as immunoprecipitation and high-throughput screening. Our team ensures that the generated polyclonal antibodies exhibit high titer, specificity, and minimal cross-reactivity.
We offer comprehensive antibody characterization services to confirm the specificity, affinity, and functionality of B8R antibodies. This includes ELISA testing, flow cytometry, immunofluorescence, and Western blot analysis. We also provide extensive support in optimizing antibodies for use in various research applications.
Creative Biolabs offers customized solutions tailored to the specific needs of each project. Whether you require antibodies with particular affinities, isotypes, or optimized conditions for specific assays, our team works closely with clients to ensure that the antibodies developed are perfectly suited to the research goals.
The B8R protein in monkeypox plays a pivotal role in the virus's immune evasion strategy. It acts primarily by inhibiting the host's interferon signaling pathway. Specifically, B8R interferes with the function of key cytokines involved in the antiviral immune response, such as interferon-alpha and -beta. This inhibition hampers the host's ability to mount a robust immune response, allowing the virus to replicate efficiently.
Furthermore, B8R has been shown to impact the activation of various immune cells, including natural killer (NK) cells and T cells. By modulating the immune system's activation and signaling pathways, B8R facilitates viral persistence and the spread of monkeypox, highlighting the protein's significance in the overall viral lifecycle.
| Cat# | Product Name | Target | Antibody Isotype | Species Reactivity | Applications |
|---|---|---|---|---|---|
| MPYF-1022-KX1594 | Anti-Variola (Smallpox) Virus B8R Monoclonal Antibody (MP-K1528) (Mouse IgG) | B8R | Mouse IgG | Variola (Smallpox) Virus | MPYF-1022-KX1594 |
| MPYF-0822-YF146 | Anti-Monkeypox Virus B8R Monoclonal Antibody (MP-W111) (Mouse IgG) | B8R | Mouse IgG | Monkeypox Virus | MPYF-0822-YF146 |
| MPYF-1022-KX1478 | Anti-Vaccinia Virus (Smallpox Vaccine) B8R Monoclonal Antibody (MP-K1407) (Mouse IgG) | B8R | Mouse IgG | Vaccinia Virus (Smallpox Vaccine) | MPYF-1022-KX1478 |
| Cat# | Product Name | Species | Expression System | Target Protein | Protein Length |
|---|---|---|---|---|---|
| MPYF-0722-KX272 | Magic™ Monkeypox virus (Zaire-96-I-16) B8R Recombinant Protein | Monkeypox virus | Based on specific requirements | B8R | Full length |
| MPYF-0922-KX729 | Magic™ Variola (Smallpox) Virus (India-1967, Ind3) B8R Recombinant Protein | Variola (Smallpox) Virus | Based on specific requirements | B8R | Full length |
| MPYF-0922-KX608 | Magic™ Vaccinia Virus (Smallpox Vaccine) (Western Reserve) B8R Recombinant Protein | Vaccinia Virus (Smallpox Vaccine) | Based on specific requirements | B8R | Full length |
| Cat# | Product Name | Species | Target |
|---|---|---|---|
| MPYF-0722-KX1474 | Monkeypox virus, B8R-F | Monkeypox virus | B8R |
| MPYF-0722-KX1665 | Monkeypox virus, B8R-R | Monkeypox virus | B8R |
| Cat# | Product Name | Species | Target |
|---|---|---|---|
| MPYF-0722-KX1283 | Magic™ Monkeypox virus B8R Expression Plasmid | Monkeypox virus | B8R |
Creative Biolabs leverages cutting-edge platforms and technologies to deliver high-quality B8R antibodies and related services:
For the generation of monoclonal antibodies with high specificity and reproducibility.
To create diverse antibody populations with recognition of multiple epitopes on B8R.
For epitope mapping and antibody selection against specific regions of the B8R protein.
Tailored to the specific needs of each project to ensure optimal immune responses.
B8R-specific antibodies have a wide range of applications in both basic and applied research:
Creative Biolabs offers several key advantages in the development of B8R-specific antibodies:
At Creative Biolabs, we employ rigorous screening and validation processes, including epitope mapping, cross-reactivity testing, and performance in multiple assay formats, to confirm the specificity of B8R antibodies. Our hybridoma and polyclonal antibody development protocols are designed to minimize off-target binding and ensure highly specific interaction with the B8R protein.
Yes, B8R antibodies are an essential tool for studying how MPXV modulates the host immune system. By detecting and tracking the interaction of B8R with immune signaling molecules, these antibodies can help elucidate the mechanisms through which the virus suppresses interferon signaling and inhibits the activation of immune cells such as NK cells and T cells.
Creative Biolabs offers custom antibody conjugation services for B8R antibodies. This includes linking antibodies to enzymes, fluorochromes, or other detectable tags for use in various assay formats. Whether you need conjugation for immunohistochemistry, flow cytometry, or other specialized techniques, our team can tailor the antibodies to meet your precise requirements.
We DO NOT PROVIDE ANY PRODUCTS OR SERVICES DIRECTLY TO PATIENTS. All of our products are for Research Use Only (RUO), NOT intended for diagnostic, therapeutic, or clinical use.