Lumpy Skin Disease Virus

Recently, viruses that resemble monkeypox virus, such as lumpy skin disease virus (LSDV), are becoming a focus of attention. These poxviruses have the ability to infect animals and humans and cause skin and systemic diseases, even leading to death. Although lumpy skin disease is not zoonotic, as a virus that infects cattle with significant economic value, conquering LSDV transmission and prevention is a top priority for Creative Biolabs. As a service provider in life science, Creative Biolabs offers reliable viral products and one-stop solutions for antiviral drug development. Our services play a critical role in preventing economic damage in the livestock industry caused by LSDV by facilitating mechanical research of viruses and the development of anti-virus agents.

Fig.1 Cattle.

Background of Lumpy Skin Disease Virus

Lumpy skin disease virus is a contagious poxvirus belonging to the genus Capripoxvirus. LSDV was first found in southern Africa and spread through the Middle East to the European countries and Russia. The natural hosts of LSDV are limited within the non-ruminants. LSDV primarily affects cattle and zebus, sometimes giraffes, water buffalo, and impalas, while goats and sheep do not develop lumpy skin disease (LSD) after exposure to this virus. Therefore, the lumpy skin disease caused by LSDV infection is not zoonosis. The susceptibility to LSDV of cattle is not constrained by cattle breed, sex, and age. Younger populations of cattle exhibit more severe clinical symptoms of infection with this virus. The clinical symptoms of LSD show fever, nodular skin lesions distributed on the cattle’s body, muzzle, nose, eyelids, limbs, scrotum, perineum, udder, and tail, and internal lesions in the respiratory and gastrointestinal mucosa, resulting in ocular and nasal discharge, reduced meat and milk production, infertility, abortion, and in severe cases death. The LSDV is transmitted via mechanical vectors, such as mosquitoes and flies. In order to reduce the burden of LSD on the livestock industry, the development of improved diagnostic tests and vaccines and the design of more effective protocols for the control and elimination of the disease are the primary goals at present.

Fig.2 Nodular lesions of LSD affected calf (a) and cow (b). (Hasib, 2021)

Lumpy Skin Disease Virus Services at Creative Biolabs

Creative Biolabs is a world-leading services provider equipped with advanced platforms and powerful technologies. We are dedicated to supporting anti-viral drug discovery by providing a full range of viral products for virus detection and research as well as developing high-quality and high-sensitivity high-throughput screening, artificial intelligence, and in vitro and in vivo platforms. Our one-stop solution allows our customers to investigate the entry, replication, proteolytic processing, and particle egress steps in the lifecycle of infectious viruses and to develop drugs for each of these processes. If you are interested in our lumpy skin disease virus services, please do not hesitate to contact us to discuss your project.

Reference

1. Hasib, F. M. Y.; et al. Lumpy skin disease outbreak in cattle population of Chattogram, Bangladesh. Veterinary Medicine and Science. 2021, 7(5): 1616-1624.