We DO NOT PROVIDE ANY PRODUCTS OR SERVICES DIRECTLY TO PATIENTS. All of our products are for Research Use Only (RUO), NOT intended for diagnostic, therapeutic, or clinical use.
Monkeypox virus (MPXV), an orthopoxvirus, has garnered significant attention due to its zoonotic transmission and potential global health impact. Among its numerous structural and functional proteins, B5R stands out as a key target for scientific research and assay development. Creative Biolabs, a trusted partner in antibody development services, offers state-of-the-art solutions for the design and production of B5R-specific antibodies to facilitate advanced research and diagnostic endeavors.
B5R is a 42-kDa glycoprotein encoded by the MPXV genome and plays an essential role in the formation of extracellular virions, contributing to virus egress and cell-to-cell spread. As a critical immunogenic protein expressed during the late stages of infection, it is an ideal candidate for research into viral pathogenesis, immune responses, and viral neutralization assays. Creative Biolabs provides comprehensive antibody development services tailored to B5R, leveraging cutting-edge platforms to deliver high-quality, research-grade antibodies.
Creative Biolabs specializes in the custom development of high-affinity antibodies against B5R to support diverse research applications. Our comprehensive antibody development services encompass:
We utilize advanced bioinformatics tools to design B5R-specific antibodies with precise epitope targeting. Services include:
Our proprietary phage display library platforms are tailored to produce monoclonal antibodies with superior specificity and affinity. Key features include:
We offer hybridoma-based monoclonal antibody generation, incorporating:
We excels in engineering recombinant antibodies to suit various experimental needs:
We offer labeling and conjugation services to enhance the utility of B5R antibodies in:
The B5R glycoprotein facilitates several critical functions in MPXV biology, making it a significant focus for research. B5R is crucial for the assembly of extracellular virions (EVs), the infectious forms of the virus that mediate long-range dissemination. It participates in the wrapping of intracellular mature virions (IMVs) with a double membrane derived from the trans-Golgi network or endosomes. This process ensures efficient release of EVs into the extracellular environment, promoting viral spread.
B5R is a key target for neutralizing antibodies due to its extracellular expression on EVs. It plays a role in immune evasion by modulating host immune responses, making it an excellent candidate for studying viral pathogenesis and antibody-mediated neutralization mechanisms.
| Cat# | Product Name | Target | Antibody Isotype | Species Reactivity | Applications |
|---|---|---|---|---|---|
| MPYF-0822-YF174 | Anti-Monkeypox Virus B5R Monoclonal Antibody (MP-W189) (Mouse IgG) | B5R | Mouse IgG | Monkeypox Virus | WB (Other applications need to be tested) |
| MPYF-1022-KX1871 | Anti-Vaccinia Virus (Smallpox Vaccine) B5R Monoclonal Antibody (MP-K1305) (Mouse IgG) | B5R | Mouse IgG | Vaccinia Virus (Smallpox Vaccine) | WB (Other applications need to be tested) |
| Cat# | Product Name | Species | Expression System | Target Protein | Protein Length |
|---|---|---|---|---|---|
| MPYF-0922-KX506 | Magic™ Vaccinia Virus (Smallpox Vaccine) B5R Recombinant Protein | Vaccinia Virus (Smallpox Vaccine) | Based on specific requirements | B5R | Full length |
| MPYF-0722-KX30 | Magic™ Monkeypox virus (Zaire-96-1-16) B5R Recombinant Protein Expressed in E. coli | Monkeypox virus | E. coli | B5R | ECD |
| MPYF-0722-KX265 | Magic™ Monkeypox virus (Zaire-96-1-16) B5R Recombinant Protein | Monkeypox virus | Based on specific requirements | B5R | Full length |
| Cat# | Product Name | Species | Target |
|---|---|---|---|
| MPYF-0722-KX1471 | Monkeypox virus, B5R-F | Monkeypox virus | B5R |
| MPYF-0722-KX1662 | Monkeypox virus, B5R-R | Monkeypox virus | B5R |
| Cat# | Product Name | Species | Target |
|---|---|---|---|
| MPYF-0722-KX1280 | Magic™ Monkeypox virus B5R Expression Plasmid | Monkeypox virus | B5R |
Creative Biolabs employs cutting-edge technologies to ensure the delivery of exceptional B5R antibody development services. These include:
Optimized for large-scale screening and selection.
Robust systems for antibody production and engineering.
Surface plasmon resonance (SPR) and biolayer interferometry (BLI) systems for real-time kinetic analysis.
Ensuring efficient identification of high-affinity B5R-specific antibodies.
B5R antibodies developed by Creative Biolabs are suited for a wide range of research applications, including:
Creative Biolabs stands out as a premier partner for B5R antibody development due to:
Yes, Creative Biolabs offers bioinformatics-driven epitope mapping services to identify novel and immunogenic regions within the B5R protein for precise antibody design.
Absolutely, we perform stability assessments under various conditions, including temperature, pH, and buffer composition, to ensure the suitability of B5R antibodies for your research applications.
Certainly, we specialize in bispecific antibody engineering, enabling the targeting of B5R alongside complementary viral or host proteins for enhanced research versatility.
We can perform detailed comparisons of binding kinetics, epitope specificity, and functional performance to help you select the most effective B5R antibodies for your study.
We DO NOT PROVIDE ANY PRODUCTS OR SERVICES DIRECTLY TO PATIENTS. All of our products are for Research Use Only (RUO), NOT intended for diagnostic, therapeutic, or clinical use.