Monkeypox virus, D1L-F(MPYF-0722-KX1309)

Target

D1L

Full Name

Ankyrin-like protein

Alternative Names

MPXVgp004; ankyrin-like protein; D1L; although the function of the ankyrin-like protein is not completely understood, it is highly conserved throughout the Orthopoxvirus genus; it is composed of ankyrin repeats and an F-box-like domain; it may be critical for overcoming cellular restriction factors; The poxviridae are enveloped unsegmented dsDNA viruses; the ankyrin-like protein of the modified vaccinia virus ankara interacts with Skp1a, a member of the Skp1a-Cullin-1-F-box (SCF) ubiquitin ligase complex; The poxviridae are enveloped unsegmented dsDNA viruses; unlike many dsDNA viruses that replicate in the host nucleus poxviruses encode their own replication machinery and therefore replicate in the cytoplasm; viral genes are expressed in a bi-phasic manner with early genes encoding non-structural proteins involved in genome replication and late genes encoding the viral structural proteins

Gene ID

UniProt ID