Human APOBEC3A Recombinant Protein Expressed in E. coli(MPYF-0722-KX36)

Expression Systems

Protein Tag

6xHis-SUMO tag at the N-terminus

Protein Length

Full Length

Protein Form

Soluble

Form

LYOPH

Reconstitution

Please see Certificate of Analysis for specific instructions.

Buffer

Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Purity

>90% as determined by SDS-PAGE

Storage

Aliquot and store at -20°C or lower. For long term storage, we recommend to store at -70°C or lower. Avoid freeze/thaw cycles.

Target Protein

APOBEC3A

Full Name

Apolipoprotein B mRNA editing enzyme catalytic subunit 3A

Introduction

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene.

Alternative Names

A3A; ARP3; PHRBN; bK150C2.1; DNA dC->dU-editing enzyme APOBEC-3A; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A; phorbolin-1; probable DNA dC->dU-editing enzyme APOBEC-3A

Gene ID

UniProt ID