Magic™ Human APOBEC3A Recombinant Protein Expressed in E. coli(MPYF-0722-KX36)
This product is a Human APOBEC3A recombinant protein expressed in E. coli. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.
Product Specifications
Protein Class
Virus-host interaction
Sequence
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Product Description
Expression Systems
E. coli
Protein Tag
6xHis-SUMO tag at the N-terminus
Protein Length
Full Length
Reconstitution
Please see Certificate of Analysis for specific instructions.
Buffer
Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Concentration
Lot specific
Purity
>90% as determined by SDS-PAGE
Storage
Aliquot and store at -20°C or lower. For long term storage, we recommend to store at -70°C or lower. Avoid freeze/thaw cycles.
Target
Full Name
Apolipoprotein B mRNA editing enzyme catalytic subunit 3A
Introduction
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene.
Alternative Names
A3A; ARP3; PHRBN; bK150C2.1; DNA dC->dU-editing enzyme APOBEC-3A; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A; phorbolin-1; probable DNA dC->dU-editing enzyme APOBEC-3A